hIL3-hCSF2-Tg(M-NSG)
品系全名
NOD.Cg-PrkdcscidIl2rgem1Tg(hIL3-hCSF2)Smoc
目录号
NM-KI-215006
品系状态
活体
基因信息
基因名
IL3
基因名
CSF2
品系描述
利用转基因技术将人源IL3和人源CSF2基因表达框整合到小鼠基因组中，从而表达人源IL3和人源CSF2。
*使用本品系发表的文献需注明: hIL3-hCSF2-Tg(M-NSG) mice (Cat. NO. NM-KI-215006) were purchased from Shanghai Model Organisms Center, Inc..
验证数据
Fig.1 Detection of hCSF2(A) and hIL3(B) expression in serum by ELISA (n=3).
Abbr. HO, homozygous; N.D. not detected.
Fig. 2 Human immune cell phenotyping in hIL3-hCSF2-transgenic (M-NSG) engrafted with human HSCs. Human CD34+ cells (1.0×10^5) were intravenously injected into homozygous hIL3-hCSF2-transgenic (M-NSG) pretreated with 1.0 Gy irradiation. These results demonstrate successful engraftment and propagation of human T, B, Myeloid and Momocytescells in the hIL3-hCSF2-transgenic (M-NSG) model.
发表文献 1篇
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